Biopharma Filtration & Bioprocessing Products Compared — 2026

Reusable hermetic disc-stack centrifuge range purpose-built for gentle mammalian cell / microbial harvest and precipitated-protein separation — the workhorse reusable counterpart to the single-use CultureOne line, spanning lab/pilot through production models (100/200/400).

Premium single-use disc-stack separator built around the patented pre-sterilized 'Spinsert' disposable bowl/disc assembly — targets biopharma manufacturers wanting centrifugal clarification without CIP/SIP turnaround between batches.

High-bowl-speed reusable centrifuge range for microbiological/pharmaceutical applications — bacteria, rDNA products, enzymes and vaccine intermediates — sitting alongside Culturefuge as Alfa Laval's non-mammalian-cell-focused separation line, with hermetic 'H' variants for oxygen-sensitive product.

A hollow-fiber microfilter distinct from the virus-removal Planova line — targets cell-culture clarification and perfusion harvest, running in tangential-flow mode to gently separate cells from product while limiting shear-driven lysis.

The original size-exclusion hollow-fiber virus filter line (commercial since 1989) built on cuprammonium regenerated cellulose membranes; the N-series pore-size ladder (15N/20N/35N) lets manufacturers match filter selectivity to the target protein's hydrodynamic radius.

Next-generation hollow-fiber virus filter built on a hydrophilized PVDF (synthetic, not cellulose) membrane engineered for pressure resistance, aimed at high-protein-concentration and large-volume batches that historically strained cellulose-based filters.

Ultrafiltration/microfiltration cassette line scaling from 0.5 L lab devices to 20,000 L process runs on a single membrane chemistry, sold in two flavors — UET (asymmetric mPES, 1-1000 kDa MWCO) for high flow/wide pH tolerance and UFC (regenerated cellulose, 1-300 kDa MWCO) for low protein binding.

0.2 µm asymmetric-PES sterilizing-grade capsule with high dirt-holding capacity for buffer/media/final fill sterile filtration; ships pre-sterilized (autoclaved), validated to the ASTM F838 bacterial-retention standard used across the industry to qualify 'sterilizing grade' claims.

Asymmetric PES parvovirus-retentive cassette line (an RC/regenerated-cellulose 20 nm variant is also offered) engineered for high fouling capacity against protein aggregates; Cobetter publishes worst-case-pressure LRV robustness data specifically for MVM (mouse minute virus), the industry's standard small-virus challenge.

Bench/pilot-scale automated TFF skid; Kvick Lab cassettes (0.11 m² each, up to three stacked per holder) give a linearly scalable concentration/diafiltration path from process development toward GMP.

0.8 µm pore convective ion-exchange membrane with binding capacity that is largely flow-rate independent, unlike packed bead resins — capsules scale from sub-1 mL XT Acrodisc lab devices to 5 L process capsules that can be gang-manifolded.

Automated, functionally-closed centrifugal cell processing (wash/concentrate/volume-reduce) for autologous cell and gene therapy workflows, running single-use rotating-seal kits on a reusable instrument.

Delta regenerated-cellulose single-pass TFF eliminates the recirculation loop of conventional TFF, concentrating product in one pass through staged membrane modules — typically used for inline final concentration ahead of fill-finish.

0.65 µm PES prefilter layered ahead of a 0.2 µm PES sterilizing-grade final membrane in one capsule; Standard/Mini/Nova capsule sizes track process volumes from roughly 30 L up to 1000 L.

Seitz-media dual-layer depth filter capsules in three interchangeable sizes; a chassis can hold two different media grades in series for combined primary/secondary clarification in one skid.

Donaldson's flagship sterilizing-grade cartridge line for compressed air, process gas, steam, and liquid filtration in pharma/biotech utilities — the workhorse behind Donaldson's narrower (vs. dedicated bioprocess vendors) but real pharma filtration footprint.

Donaldson's Purilogics acquisition added resin-free membrane adsorber chromatography to its bioprocess portfolio, distinct from its legacy air/gas/liquid utility filtration business — Purexa NAEX targets plasmid DNA and nucleic-acid purification, now with GMP-grade manufacturing available.

Double-layer pleated PES membrane cartridge (0.2 µm pre-filter layer protecting a 0.1 µm final layer in one element) built for economical sterile filtration of life-science liquids, fine chemicals and cosmetic actives — positioned by Eaton below dedicated 0.2 µm sterilizing-grade cartridges used for final drug-product filtration.

Small-format ready-to-use capsule built around BECOPAD P cellulose depth filter sheets, used for lab-scale media screening and scale-up trials (cell debris removal, serum/cell-culture-media filtration) ahead of BECODISC selection at production scale.

High-purity cellulose stacked-disc cartridges (no mineral filter-aid components), built from BECOPAD depth filter sheets, spanning microbial-removal grades through coarse clarification/catalyst recovery grades in one cartridge family.

Wide-pore polypropylene prefilter line that sits upstream of Entegris's 0.22 µm Pharmsteri II sterilizing filters, protecting them from bioburden and particulate load in clarification/prefiltration duty.

Entegris's core biopharma liquid-filtration line — 0.22 µm hydrophilic PES capsules for buffer/media/product sterile filtration plus a hydrophobic dual-layer UPE vent-capsule variant for tank and bioreactor gas venting.

Disposable alluvial (diatomaceous-earth precoat) depth filtration system that clarifies fermentation broths and cell harvest streams in one step, removing up to 30–40% of HCPs alongside cells/debris. Scales from 2" lab capsules (<1 L) to 16" production modules (~600 L per module).

Cellulose depth filter sheet media for reusable filter-press/module hardware, purpose-built for biological and pharmaceutical purity requirements. The PF grade is specifically optimized for blood plasma fractionation with further-reduced endotoxin levels.

Single-use disc-stack centrifuge line spanning bench (kytero 10, 1-10 L bioreactors) to production scale (kytero 2000, up to 2,000 L) with fully closed, biocontainment-proof flow paths — positioned against conventional reusable separators for cell/gene therapy and intensified perfusion processes where cross-contamination risk and CIP/SIP turnaround matter more than raw throughput.

Reusable, fully SIP/CIP-capable disc-stack separator built for the strictest hygienic tier — vaccines, mAbs, insulin, starter/probiotic cultures — with a water-cooled IDD drive and closed housing to prevent cleanroom emissions; GEA markets it as a distinct line from the lower-hygiene 'pure' series, not a configuration option of it.

The flexibility-first sibling to Aseptic X — same bowl-design family and solids-handling range but tuned for varying (not maximal) hygienic requirements: therapeutic protein recovery, pharmaceutical extraction, and intracellular/extracellular enzyme recovery rather than sterile vaccine/mAb lines.

Sanitary heat-sanitizable reverse-osmosis elements purpose-built for pharmaceutical, dialysis and semiconductor ultrapure-water polishing — packaged in a hard-shell format with diamond feed spacers to cut bypass flow versus standard net-wrapped RO elements.

Hot-water-sanitizable ultrafiltration hollow-fiber module line used in pharma WFI/ultrapure-water pretrain and biomolecule concentration/purification duty — MANN+HUMMEL's bioprocess-relevant angle is water-system membranes rather than direct-contact process filters.

Meissner's dedicated hollow-fiber TFF platform for cell retention/clarification and UF/diafiltration, spanning gamma-sterilized single-use capsules through steam-in-place reusable cartridges for stainless housings — the company's answer to cassette-based cross-flow.

Meissner's broad sterilizing-grade membrane family covers both hydrophilic (PVDF/PES, for aqueous liquids) and hydrophobic (PVDF/PTFE, for gas/vent duty) chemistries across the same pore range, letting a process standardize on one vendor for liquid and gas sterile filtration alike.

Purpose-built for final fill/finish PUPSIT workflows — a single striped/pleated PVDF membrane combines sterilizing-grade hydrophilic and hydrophobic zones so one filter can wet, integrity-test, and dry faster than swapping separate liquid and vent filters.

Benchtop Type 1 ultrapure water polisher with on-board TOC monitoring; sized for analytical and small-scale buffer prep rather than bulk manufacturing water-for-injection systems.

D0HC (primary) and X0HC (secondary) media grades pair for two-stage cell-culture harvest clarification; pod areas scale from lab discovery through process pilot sizes.

Nanofiber-based (not cast-film) convective anion-exchange adsorber marketed for higher dynamic binding capacity than conventional membrane chromatography at comparable residence times.

Ultracel composite regenerated-cellulose membrane cassettes scale linearly from an 88 cm² lab-scale device to a 1.14 m² process-scale cassette at fixed channel geometry, easing tech transfer.

Composite flat-membrane construction targeted at parvovirus-class clearance; commonly qualified around 150 L/m²/h flux with a 2.0 bar pressure drop in vendor QbD studies.

PROPOR SG is Parker's validated 0.2 µm sterilizing-grade PES filter for routine pharma liquid filtration; PROPOR HC is the high-capacity variant engineered to extend throughput on viscous or high-bioburden biologic feeds before premature blockage.

Modified-PES hollow-fiber TFF range spanning microfiltration (cell/lysate clarification) and ultrafiltration (mAb concentration/diafiltration) in reusable, single-use, and autoclavable formats — positioned as a lower-cost-per-membrane-area alternative to cassette TFF.

Automated TFF process-control skids that pair with PROPOR TFF or third-party hollow-fiber/cassette consumables, scaling the same control platform from bench feed rates up to full GMP manufacturing runs.

The FRP housing hardware that racks X-Flow (or third-party) UF/RO membrane elements into a working skid for pharma-grade water systems — a hardware complement to the membrane media rather than a filtration consumable itself. Included as a real, distinct Pentair product line marketed into pharma alongside X-Flow; flagged low confidence because an earlier research pass mis-cited a non-existent 'Fairfield' brand for this slot — Codeline is the verified real product.

Pressurized inside-out PES/PVP hollow-fiber UF module manufactured at X-Flow's Enschede (NL) site; deployed as pretreatment ahead of reverse osmosis in Purified Water, Highly Purified Water and Water-for-Injection generation trains for pharma manufacturing — not a process-stream (mAb/virus) filter, but the ultrapure-water backbone many biopharma plants run on.

Porvair's sterilizing-grade liquid filtration line for pharma/biotech, built on a naturally hydrophilic PES membrane with a built-in asymmetric prefiltration layer to extend service life ahead of the final sterilizing layer.

Hydrophobic Gore ePTFE membrane cartridges dedicated to sterile gas/vent filtration (e.g. fermenter air feed) rather than liquid product streams — a distinct application niche from the Biofil liquid line.

Multi-layer graded polypropylene depth filter used as upstream clarification/prefiltration ahead of sterilizing-grade membranes — reduces fouling load on the final Biofil/Fluorofil stage.

KR2i is the lab-scale instrument (2 mL–15 L process volume); KMPi is the pilot-scale sibling (0.1 L–500 L+) with the same control philosophy scaled up, supporting both hollow-fiber and flat-sheet cassette formats.

Gamma-irradiated, fully closed single-use flat-sheet cassette line — 96 configurations across MWCO and area let a process scale from 0.1 m² development runs to 10 m² manufacturing without changing hardware format.

Alternating tangential flow (not continuous cross-flow) hollow-fiber cell-retention devices for high-density perfusion; ATF2 through ATF10 sizes scale bioreactor working volume from bench to manufacturing with less shear than constant-flow TFF.

CAUTION: legacy entry. Novasep's chromatography process-equipment division (Prochrom®, Hipersep®, BioSC®) was divested to Sartorius in Feb 2022 and is no longer sold under the Novasep brand; Novasep itself merged with PharmaZell in 2022 to form Axplora, a CDMO with no current equipment product line. Retained here only for historical completeness, relabeled to the current owner.

Convective salt-tolerant ion-exchange and affinity membrane adsorbers (Q, S, Phenyl, Protein A chemistries) run at flow rates unreachable with packed resin, at the cost of lower per-cycle capacity.

Dual-layer DL-series clarification grades (DL90 through DL10) span cell-culture harvest clarification from 25 cm² lab caps to 3.7 m² process modules.

Bench-to-pilot TFF skids paired with single-use Sartocon® cassette holders; Slice covers early process development, Smart scales toward pilot manufacturing.

Double-layer 0.45+0.2 µm PES membrane gives high-throughput sterilizing-grade filtration, validated per ASTM F-838 across capsule, Midicaps, Maxicaps, and 10-inch cartridge formats.

20 nm-rated hollow-fiber PES virus-retentive membrane scales from a 5 cm² lab discovery module to a 1.0 m² process module while preserving validated LRV across scales.

Thermo Fisher's long-running lab-scale vacuum/bottle-top sterile filtration line for media, serum, buffer and additive filtration during process development — not intended for GMP manufacturing-scale filtration, which routes through the separate single-use assembly and (post-acquisition) Zeta Plus/LifeASSURE lines below.

Configurable, GMP-manufactured tubing/manifold/filter/bioprocess-container assemblies (secured with Thermo's BioTitan Retention connectors) that carry sterilizing-grade filters into closed, single-use process trains — the connective-tissue product line between Nalgene lab filters and full-scale single-use manufacturing, built via Thermo Fisher's online Assembly Configurator rather than sold as one fixed SKU.

The harvest-clarification depth filter franchise Thermo Fisher acquired with Solventum's ~$1B-revenue Purification & Filtration business (deal closed Sept 2025); spans charged (ZB), broad-pore (SP), low-extractable (LA), activated-carbon and viral-burden-reduction (VR) media grades in capsule, cartridge, or filter-press-sheet format, scaling from benchtop capsules to production cartridges on the same media chemistry.

Expanded PTFE (ePTFE) membrane media sold as pleated cartridges, capsules, in-line filters, and cut disks, used mainly for sterile gas/vent filtration (fermenter air supply, tank venting) and hydrophobic liquid/aerosol retention rather than sterile liquid filtration of the drug product itself.