Which automated sampler fits your process?
A vendor-neutral census of real autosampler and automated-sampling product lines — not vendors — for biotech & pharma, scored on fit and disclosure rather than on marketing claims. Filter by segment, pricing model, hardware lock-in and region.
- Makers
- 38
- Product lines
- 85
- Datasheet-confirmed
- 43 rows
Lab-equipment comparison · 2026
Autosamplers & automated sampling, compared product-by-product
A vendor-neutral matrix of 85 autosampler / automated-sampling product lines from 38 makers for biotech & pharma, across 5 market segments — from bioprocess-aseptic samplers that pull sterile samples straight from bioreactors, to analytical autosamplers in QC/release labs, general-purpose liquid-handling robots, and process-analytics samplers. Compare the axes that actually drive the choice: pricing model (perpetual vs subscription) and hardware lock-in (vendor-agnostic vs platform-specific). Every row is confidence-marked against vendor datasheets; where a spec isn't public we say so. Several vendors ship more than one product line — each gets its own row.
85
Products
38
Makers
17
Bioprocess / aseptic
19
Vendor-agnostic
72
Perpetual-license
At a glance
How the field breaks down
Of 85 products — where they compete and how they charge. Analytical (QC) autosamplers are the most crowded segment; the dedicated bioprocess-aseptic niche is smaller and splits sharply between perpetual-license challengers and subscription-software incumbents.
Products by segment
- Bioprocess / aseptic17
- Analytical (QC)36
- Liquid handling5
- Process analytics19
- R&D automation7
- Exited1
Products by pricing model
- Perpetual72
- Instrument + services2
- OEM / consumables9
- n/d2
The field
85 of 85 products
| Pricing | Hardware | Conf. | |||
|---|---|---|---|---|---|
| BBI-Biotech Germany | bioPROBE single / orbitSAM Autosampler The entry-level bioPROBE configuration — one probe per vessel feeding a simple auto-sorting carousel (orbitSAM), positioned as BBI-Biotech's budget automated sampler for single-reactor setups. Capacity conflicts between BBI's own sources: the live product page says 36 positions with a 51 × 15 mL rack still 'in development', while an older PDF claims 51. The shipping figure is used here. Note the barrier is mechanical, not a filter, and this is a positive claim rather than a gap: BBI's flyer sells 'unique filterless sampling technology' and 'no filters in the bioreactor, no issues with biofilms / biofouling'. So a pore size here would be wrong, not merely unsourced — the 0.2 µm that surfaces in search results is a Flownamics FISP probe's, a different vendor's part. The interval comes from BBI's dedicated bioPROBE technical-data page, whose table is headed 'valid for all bioPROBE Systems' — a spec table, not a leaflet, and byte-stable across captures from 2015 to 2021. Two things a future editor needs to know about it. First, it is gone: the live site publishes no number at all ('Die Probenintervalle sind frei wählbar'), the downloads page 404s and the sitemap is an empty urlset, so the archived URL is the citation and there is no live one to upgrade to. Second, BBI's own 2015 bioPROBE flyer disagrees with it, saying 'Sample interval: up to 5 min' ('bis zu 5 min') — do NOT cite the two as agreeing. The technical-data page wins on all three axes: it is a spec table rather than a two-page leaflet, it says 'from' (a minimum interval, which is what a sampler spec means) where the flyer's 'up to' reads as an upper bound and so is ambiguous in the wrong direction, and it is the later of the two. That the gap is real and not a search failure is corroborated third-party: Efromson 2021 (HardwareX) tabulates competing bioreactor autosamplers with a 'Minimal Sampling Interval' column and the bioPROBE cell reads NA while Omnicoll, EasySampler and BioSamplr carry numbers. Four published numbers sit close enough to be mistaken for this product's and none is: the 'bbi-biotech GmbH, Berlin' cited in Processes 2019 and 2022 is an IMPELLER (three-blade segment, 54 mm, 30°), not a sampler; the Eppendorf application note's 'Sampling frequency Every 2 h' is Eppendorf's own; Rupcic 2018 (PMC6027269) ran a bbi xCUBIO reactor with an UNNAMED aseptic probe — plausibly this one, unprovable, so it is not cited as a use; and Kuystermans 2014 cites BBI but sampled on an MSP FCP 5000 whose 'every 5 h' is that machine's. There are zero verifiable academic uses of bioPROBE, orbitSAM, multiSAM, coolSAM or iceBLOCK anywhere. | Bioprocess / aseptic | Perpetual | OEM cross-brand | Med |
| BBI-Biotech Germany | bioPROBE quad / multiSAM Autosampler The scale-up configuration — four independent probes feeding one multiSAM that can hold hundreds of cooled samples, built for parallel small-scale screens rather than one large vessel. The richest of BBI's line: 40+ extension packs including filtration (96-well plates, Chromafil cartridges, MediaKap hollow fibre) and a 21 CFR Part 11 / Annex 11 audit-trail pack. Careful with the filtration packs — those are post-draw sample prep, not the sterile barrier, which is the probe valve. BBI publishes no cooling temperature for the Peltier pack; the ThermoStat C's own range is a third-party number and is not quoted here. The interval below is NOT inferred from the sibling row — BBI's bioPROBE technical-data table is explicitly scoped 'valid for all bioPROBE Systems', and single and quad are the two members, so it lands here in its own right. What is genuinely unpublished is the thing this configuration exists for: no multiSAM-level or per-reactor throughput figure exists anywhere, so 'time to service four reactors' has no answer and nothing says whether four probes cycle concurrently or in turn. Same for the analyzer count — 'unlimited atline processes' in the product presentation is marketing, not a countable spec, and must not be tabulated as one. See the bioPROBE single entry for why the archived 2015 flyer's conflicting 'up to 5 min' loses to that table, and for the four nearby published figures (a bbi IMPELLER in Processes 2019/2022, Eppendorf's own 2 h, Rupcic 2018's unnamed probe, and an MSP FCP 5000's 5 h) that must not be attributed to this product. | Bioprocess / aseptic | Perpetual | OEM cross-brand | Med |
| BBI-Biotech Germany | coolSAM Autosampler DISCONTINUED, and no longer merely 'probably' — its own product URL returns HTTP 301 Moved Permanently in both languages, redirecting into the generic automated-sampling page. A 301 rather than a 404 or a 302 is a deliberate permanent retirement, and it is recent: the page was still serving 200 in a May 2026 capture. The successor is iceBLOCK, which BBI's current architecture page puts in exactly this slot ('bioPROBE quad + multiSAM + iceBLOCK') with 96 water-free Peltier positions against coolSAM's 8; coolSAM is absent from that page in both languages. One thing will confuse a fact-checker: the sampling-overview page STILL lists coolSAM third among autosamplers, but its link points at the URL that 301s — a stale nav entry with a dead link, not evidence the product is current. The page content itself was byte-identical from 2015 to 2026, i.e. frozen for eleven years and then redirected. Kept here because installed units exist and its one unusual capability is worth knowing: it heats as well as cools, for deactivating cells or triggering a thermal step in the vial. Three cells are blank and all three are closed dead ends, not gaps. Line count: BBI states this product's capacity only in POSITIONS and never in reactors, and the likeliest misreading of the whole row is turning '4 sample vessels à 50 mL' into '4 reactors' — it is neither 1 nor 4. Sampling interval: the bioPROBE technical-data table that carries 'from 2 min' is scoped to bioPROBE SYSTEMS, and the coolSAM page's own Technical Details table has exactly three rows (Size, Variants, Tempering) with no interval row ever — and unlike the quad, whose page states outright that it is four bioPROBEs, nothing says which bioPROBE configuration a coolSAM shipped against, so there is no bounded inference to make. Analyzer coupling: BBI's own pitch is 'the concentrated analysis later on', i.e. deferred bench work, and no analyzer is ever named on this page — the named packs (MACSQuant, Vi-CELL XR, SIAS) all attach to the multiSAM. | Bioprocess / aseptic | Perpetual | OEM cross-brand | Low |
| Cytiva (Danaher) United States | Xcellerex Sample Manifold A passive single-use 'seal-and-store' consumable for Cytiva's Xcellerex XDR bioreactors and XDUO/XDM mixers — an operator draws into a bag and seals it, so interval, dilution and analyzer coupling are structurally inapplicable rather than merely unpublished. Sample volume is the opposite case and is the one cell left blank — treat it as a closed dead end, not an unfinished row. Cytiva identifies this SKU by BAG COUNT ONLY, and that holds at every level of the record: no datasheet, IFU or spec table exists (both product pages literally read 'No documents available' and 'No overview available'), the XDUO ordering table's parenthetical is the bag count with no volume column beside it, and the printed product label itself — photographed on a resale listing, 'Single Use Sample Manifold -10 Bag', doc B103841-I Rev F — carries lot, expiry, storage range and quantity but no volume. A sweep of Fisher, VWR/Avantor, Thermo, Sigma-Aldrich, LabX, eBay, DotMed, EquipNet, Surplus Solutions, BioSurplus and the reseller's own site search returned the part with a count and never a volume. Two machine-readable channels say the same thing: Cytiva's own structured product API returns for 29041167 only 'Wetted Materials: C flex tubing, ULDPE' and 'Wetted Part: Yes' with an empty feature array for 29041165 (29041166 is absent from the US catalogue entirely), and the IFU URL pattern d3.cytivalifesciences.com/prod/IFU/[part-number].pdf — verified live for an unrelated part, 29277632 → 200 — 404s for all three of these. A separate sweep of the LEGACY record — four GE Healthcare data files, two GE Operating Instructions (one 322 pages, one 11k lines, both with zero occurrences of the word 'manifold'), and five original Xcellerex Inc. brochures and datasheets from 2006–2012 — found the product only ever as a catalog line or a one-clause aside ('sample manifolds are available optionally'). GE/Xcellerex never published a spec sheet for it either, so this is not a Cytiva-era omission. The only documents that could still carry the number are the XDR-50 to 2000 Operating Instructions 29-0646-43 AA (no reachable mirror) and the IFU shipped in the box, doc B103841-I Rev F — both a support request away, neither on the open web. Numbers that sit nearby and are NOT this product's: the 1/8 in swabbable sample line (the host biocontainer's), 27.5–45 kGy gamma (the XDM bags'), ReadyCircuit 50/250/500 mL sample bags (a different family), and every XDR/XDM working volume from 10 L up. One SKU caveat, confirmed twice from the live parts table: Cytiva binds 29041167 → 888-0430 and 29041165 → 888-0431, while 888-0755 appears only in a single dead eBay title and resolves nowhere in any GE or Xcellerex document — treat it as superseded or a repack, not as a third variant. | Bioprocess / aseptic | OEM / consumables | Platform-specific | Med |
| Distek United States | BIOne 1250 Bioprocess Control Station (automated sampling) Listed for completeness, and the honest answer is that it is a bioprocess CONTROL STATION with no documented automated sampling: Distek's own 2025 brochure spec table covers working volume, agitation, gas, temperature, pumps (4 bi-directional peristaltic per side) and PAT I/O, and carries no sampling row at all. What it offers is signal integration for third-party probes, not physical sample withdrawal. Distek does sell an autosampler — in its dissolution-testing line, an unrelated product family whose numbers must not be carried across. | Bioprocess / aseptic | Perpetual | Platform-specific | Low |
| Eppendorf Germany | Bioprocess Autosampler Bolts directly onto Eppendorf's own DASware-controlled bioreactor line (DASbox, DASGIP, SciVario twin, BioFlo 320) — deep, retrofit-friendly integration but zero cross-brand support. It is a sample COLLECTOR, not an analyzer feeder: draws into a chilled vial for offline analysis, with a reusable needle and wash cycles rather than a single-use fluid path. | Bioprocess / aseptic | Perpetual | Platform-specific | High |
| Flownamics United States | Seg-Flow S3 Automated Sampling System The workhorse Seg-Flow platform — reusable pinch-valve hardware with non-contact ultrasonic sensors that routes native or pre-diluted samples from up to 8 vessels to downstream analyzers, vendor-agnostic on both ends. Two numbers not in the table because the sources disagree: dilution ratio (Flownamics publishes none; distributors quote 1:10, 1:20 and 1:25) and reactor count beyond 8 (an ASR+ / FlowWeb release is claimed to double it to 16). Storage is the separate FlowFrac 1000, not the S3 itself. | Bioprocess / aseptic | Perpetual | Vendor-agnostic | High |
| Flownamics United States | Seg-Flow S3G Autosampling System S3G is the S3 chassis reconfigured specifically for blood-gas-analyzer coupling — same pinch-valve hardware, with a fluid path built to stop gases diffusing out before pH/pCO2/pO2 is read. Interval and volume are blank deliberately, and a future editor must not 'fix' them: no S3G datasheet, manual or brochure exists anywhere in Flownamics' literature library, its own Product Specifications tab is four rows (Dimensions, Weight, Electrical, System Control), and that tab reproduces the S3 brochure's Electrical/System Control/Physical rows while omitting exactly Sample Cycle and Sample Size. The mechanism of the usual misattribution is on the page itself: its 'Literature' tab links the S3 brochure, whose header reads Model: S3 and which never says S3G. So the 10–45 min and 1.25–50 mL figures are the sibling's, and the S3G's own pitch is 'minimum sample volume' with no number attached. | Bioprocess / aseptic | Perpetual | Vendor-agnostic | Med |
| Flownamics United States | Seg-Flow PS Sampling System Built for cell & gene therapy: a fully disposable, low-shear fluid path replaces S3's reusable tubing set, trading reusability for GMP traceability and zero cross-contamination risk in a small-footprint, per-bioreactor module. It is the one Seg-Flow that needs no ASR at the vessel. A US distributor advertises 24 reactors; Flownamics' own spec table, brochure and European distributor all say 16, so 16 is what's quoted here. Sampling interval is blank because the March 2024 brochure — the only PS document Flownamics publishes — has no cycle-time row in its specification panel at all; the sole claim anywhere is a distributor's qualitative 'fully customisable sampling intervals', which is not a number. | Bioprocess / aseptic | OEM / consumables | Vendor-agnostic | High |
| Merck Germany | MAST Autosampling Solution Originally Lonza's platform (developed in Bend, OR), acquired by Merck in 2022 — the only GMP-qualified automated aseptic sampler in this set built for large-scale stainless-steel manufacturing, not just bench-scale R&D. No vendor publishes a minimum sampling interval; the nearest number is ~4 min *transit* time to a nearby analyzer, which is not a cycle time. Storage and dilution are properties of the optional Gilson liquid handler, not of MAST itself. | Bioprocess / aseptic | Instrument + services | Vendor-agnostic | Med |
| Merck Germany | NovaSeptum GO Sterile Sampling System Manual, not automated — a no-dead-leg single-penetration sampling unit for multi-use/stainless-steel processes, included as Merck's aseptic-sampling counterpart to MAST for facilities that haven't automated sampling yet. Four columns below read 'not applicable' rather than sitting blank, and the difference matters: a person carries the sample, so there is no interval, no cooled bay, no dilution and no analyzer path. That is a fact about the product, not a gap in the research. Note the standard GO unit is NOT autoclavable — a separate autoclavable vented bag line exists for that. | Bioprocess / aseptic | OEM / consumables | Vendor-agnostic | High |
| Merck Germany | NovaSeptum SURe Sterile Sampling Assemblies The single-use sibling to NovaSeptum GO — same closed, no-dead-leg concept, but joined by C-Flex weld or AseptiQuik S connector into a single-use train rather than clamped onto stainless steel. Manual, so the same four columns are not applicable for the same reason. Volumes below are Merck's own summary-table figures; individual SKUs widen them (a 5 × 50 mL bag manifold ships as AC71410050 against a table that says 100 mL), so check the part number before quoting. | Bioprocess / aseptic | OEM / consumables | Vendor-agnostic | High |
| Nova Biomedical United States | BioProfile FLEX2 On-Line Autosampler (OLS) Bridges Nova's FLEX2 bench analyzer to up to 10 bioreactors via automated line draws, turning a normally manual grab-sample workflow into near-hourly PAT-grade sampling — the tradeoff is you're locked into Nova's proprietary MicroSensor Card consumables for every reading. Watch the two volume figures: 5.6 mL leaves the bioreactor per draw, of which the analyzer itself consumes 265 µL. Chilled storage is the optional SRCS rack, not standard. | Bioprocess / aseptic | OEM / consumables | OEM cross-brand | High |
| Nova Biomedical United States | BioProfile FLEX2 External Sampling Module (ESM) for Ambr® Frequently miscredited to Sartorius; it is Nova's module, and Sartorius' own integration brochure says so outright ("Ambr systems are provided by Sartorius; Nova BioProfile FLEX2 and ESM are provided by Nova Biomedical"). It is also not a bioreactor-side sampler: the Ambr robot draws the sample itself and dispenses it into a cup on the ESM deck, so the sterile barrier is the Ambr's own biosafety cabinet, not anything the ESM provides. | Bioprocess / aseptic | Instrument + services | OEM cross-brand | High |
| QB.systems (A4BEE)A4BEE Poland | QB AutoSampler Perpetual license + vendor-agnostic retrofit (OPC-UA/MQTT/REST) spanning sampling, dosing, filtration and bioreactors on one stack; fast case-study deployments. Newest entrant, small team, no issued-patent estate. | Bioprocess / aseptic | Perpetual | Vendor-agnostic | Med |
| Sartorius Stedim Biotech France | Ambr® Analysis Module Listed for completeness and it is NOT an autosampler: a pH + Raman measurement accessory that the Ambr robot feeds, so it competes with the analyzer half of a sampling chain rather than the sampling half. FOUR published spec sets exist, and they are successive editions rather than contradictions — (A) Pub. SBI1558-e160401 Ver. 04|2016: 60 µL, 90 s; (B) 'Ambr Analysis Module — pH Calibration and Raman Spectroscopy Integration' Ver. 2020/03: 60 / 250 µL, 90 / 120 s; (C) 'Integrated Cell Culture Analyzers' Ver. 06|2020: 0.06 / 0.3 mL, 1.5 / 2 min; (D) the Analysis Module brochure status 11|08|2021, republished unchanged 03|2022 and 11|2025: 60 / 200 µL, 160 s. D is what Sartorius publishes today and is what the cells above carry; quote D and cite the edition, because all four are still reachable online. Storage is sourced at page level from §8 of the Ambr 15cc User Manual (TAP-9670-06-005 Iss. 9.00, 01 May 2019): §8.7.5.2 p.161 — the tip's 'entire contents … including headspace gas is dispensed into the sample cup and immediately aspirated into sample flow channel'; §8.5.1.1 pp.152–153 — the waste bottle holds 'all samples, calibration fluid and wash fluid for a complete reagent pack' and 'most mammalian and microbial cell lines will not survive in the waste bottle since they are mixed with wash fluid in the syringe'; §8.7.6 p.163 — the 'analysis module pH cell does not have active cooling'. The §8.1.1 component list names no rack, carousel, plate or cooled position at all. The Raman path ends the same way per a source that is not Sartorius: Sensors 2022;22(9):3397 — 'to prevent sample carryover, the sample was discarded following spectral analysis and a cleaning cycle was initiated'. Dilution is a hard negative rather than an unsearched cell: the string 'dilut' occurs nowhere inside the §8 addendum; reagent kit 001-4B60 ships rinse, cleaning solution and two calibration buffers and no diluent; and Fig. 90's volume budget is closed — 700 µL headspace gas + 60 µL sample + 50 µL gas in a 1000 µL tip, all dispensed and all aspirated — so no diluent has anywhere to enter. Diluting would also defeat the measurand, since pH shifts on dilution. Numbers that sit close enough to be misread onto this module, none of which belong to it. Volume and time: the 160 µL one row above 'Cycle time per reading, pH' in the 2020/03 brochure is the Ambr 15 BioPAT Spectro sample volume, not the 160 s cycle; '0.3 (undiluted)' and '0.55 (undiluted)' in the 06|2020 brochure are the Roche Cedex HiRes and Beckman Vi-CELL XR columns. Cooling: 'cooled culture stations' and 'chilled plate positions' are the Cooled Ambr 15 Workstation 24C/48C (manual §6) — the base system, not this module. Dilution: the 1:2 ratio printed one column away on Sartorius' Integrated Analytics poster is the Nova FLEX2's; the 1:4 / 1:10 / 1:20 in Machleid 2026 and the '2- or 4-fold diluted … prior to adding to the sample cup' in the Vi-CELL BLU app note are both Vi-CELL prep performed by the base Ambr liquid handler; automated 'spiking' of samples with analyte stock solutions is Raman DoE calibration-model building, not analytical dilution; and the diluting step in the TAP patent family (US 11,598,720) is sited at the bioreactor module's manipulation station, which that same patent defines as a different part of the machine. The patent also describes routing a sample back to the bioreactor for off-line reference — a claimed alternative workflow, not storage and not shipped behaviour, so it does not reopen the storage cell. | Bioprocess / aseptic | OEM / consumables | Platform-specific | High |
| SecureCell Switzerland | Numera 3 The deepest analyzer-agnostic sampling stack in this set — modular multiplexer, dilution, filtration and routing modules built to feed almost any downstream instrument (HPLC, Cedex Bio HT, Vi-CELL, Nova Flex) rather than lock buyers into one brand. Numbers below are Numera 3; an installed V2.x system runs to the older catalogue limits (dilution to 1:30, four analyzers), so confirm the generation before quoting. | Bioprocess / aseptic | Perpetual | Vendor-agnostic | High |
| Advion Interchim Scientific United States | TriVersa NanoMate VENDOR CORRECTION: TriVersa NanoMate is manufactured by Advion Interchim Scientific (Ithaca, NY; parent Bohui Innovation Biotechnology, via the 2020 Interchim merger) — no evidence was found that Gilson ever owned, licensed, or rebranded this product. Gilson's actual 2021 mass-spec integration was Advion's separate Compact Mass Spectrometer line folded into Gilson's VERITY prep-chromatography portfolio, a different product. Chip-based nanoelectrospray ion source confirmed compatible with multiple third-party MS platforms (Waters Xevo/SYNAPT, Sciex, others). | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| Agilent Technologies United States | 1290 Infinity II Vialsampler Agilent's standard-throughput UHPLC autosampler — single-needle design pitched at routine QA/QC and method-development labs that don't need the Multisampler's dual-needle speed or 6,000+ sample capacity. | Analytical (QC) | Perpetual | Platform-specific | High |
| Agilent Technologies United States | 1290 Infinity II Multisampler Dual-needle design overlaps sample draw with the previous injection cycle, pushing cycle time down to ~5 s and capacity up to 6,144 samples — built for high-throughput labs running unattended batches, not routine single-sample QC. | Analytical (QC) | Perpetual | Platform-specific | High |
| Bio-Rad Laboratories United States | C-96 Autosampler Purpose-built loading accessory for Bio-Rad's BioLogic DuoFlow protein purification system rather than a standalone chromatography autosampler; optional Peltier cooling protects heat-sensitive protein/antibody samples during queued injections. | Analytical (QC) | Perpetual | Platform-specific | Med |
| Bio-Rad Laboratories United States | Model AS-100 Autosampler Legacy refrigerated autosampler for Bio-Rad's discontinued BioLogic HR/HRLC systems; no longer listed in Bio-Rad's current catalog and only available through the used-equipment secondary market, illustrating that Bio-Rad has since exited direct autosampler manufacturing in favor of NGC-to-third-party integration. | Analytical (QC) | Perpetual | Platform-specific | Low |
| Bruker Corporation United States | Elute+ Autosampler SL Split-loop LC-MS autosampler for Bruker's Elute+ platform, tuned for the low-carryover, high-reproducibility injections that QC/release LC-MS/MS methods (e.g., pesticide, residue panels) require; ships with PFAS-free flow-path options. | Analytical (QC) | Perpetual | Platform-specific | High |
| Bruker Corporation United States | Elute+ HT System Autosampler (PAL RSI) High-throughput sample-handling tier of the Elute+ platform built around a third-party CTC Analytics PAL RSI autosampler rather than a Bruker-native mechanism, expandable with additional sample trays for high-volume QC/release workflows and online extraction. | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| Bruker Corporation United States | SampleXpress Compact NMR sample changer for Bruker Avance spectrometers, using interchangeable cassette modules with a built-in barcode reader — aimed at standard-throughput NMR QC service labs rather than the very-high-throughput SampleJet line. | Analytical (QC) | Perpetual | Platform-specific | Med |
| Bruker Corporation United States | SampleXpress Lite Entry-level companion to SampleXpress with a smaller removable carousel, aimed at labs that need basic batch NMR sample submission without full SampleXpress cassette capacity. | Analytical (QC) | Perpetual | Platform-specific | Low |
| Bruker Corporation United States | B-ACS 60/120 Automatic Sample Changer Bruker's original automated NMR sample-changer line (predates SampleXpress), offered in 60- and 120-position configurations for unattended queued acquisitions across a wide range of Bruker field strengths. | Analytical (QC) | Perpetual | Platform-specific | Med |
| CTC Analytics / Trajan Switzerland | PAL RSI (Robotic Sample Injection) Entry-level automated injector with manually exchanged tools; supports liquid, headspace and SPME sampling on one modular platform and is field-upgradeable to full PAL RTC tool-changing. OEM'd across Agilent, Thermo, Shimadzu and other GC/LC brands. | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| CTC Analytics / Trajan Switzerland | PAL RTC (Robotic Tool Change) Robotic tool-changer that switches between liquid injection, headspace and SPME within one sample list in under 30 seconds, enabling unattended 24/7 multi-technique workflows. OEM'd widely across instrument brands rather than sold only under the CTC/Trajan name. | Analytical (QC) | Perpetual | OEM cross-brand | High |
| CTC Analytics / Trajan Switzerland | PAL DHR (Dual Head Robotic) Two independent robotic heads run parallel workflows (e.g. simultaneous headspace prep plus GC/LC injection into two systems), roughly doubling throughput versus single-head RTC/RSI configurations for high-volume QC/release labs. | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| Gilson, Inc. United States | GX-274 ASPEC (Automated SPE and Liquid Handling System) Gilson's high-throughput SPE/cartridge automation platform (1/3/6 mL cartridges), built as an open modular liquid handler intended to bolt onto third-party LC/MS front ends rather than a closed proprietary analytical stack. | Analytical (QC) | Perpetual | Vendor-agnostic | High |
| HTA S.r.l Italy | 2000H Headspace Autosampler Dedicated static-headspace autosampler that heats/shakes up to 6 vials simultaneously and relocates between GC systems from different brands in under 5 minutes; the 2000HT variant extends oven/syringe temperature for high-boiling-point applications. | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| HTA S.r.l Italy | 2800T All-In-One Autosampler Single autosampler head that covers liquid, static headspace and SPME injection and switches between the three modalities in about 5 minutes without hardware changes — a lower-cost, single-technique-at-a-time alternative to CTC's true tool-changing PAL RTC. | Analytical (QC) | Perpetual | OEM cross-brand | Med |
| JASCO Japan | AS-4050 Autosampler Routine, general-purpose autosampler in JASCO's LC-4000 series for conventional HPLC; full-loop mode maximizes reproducibility for repeat serial injections, partial-loop mode lets users change injection volume without swapping loops. | Analytical (QC) | Perpetual | Platform-specific | Med |
| JASCO Japan | AS-4150 Autosampler RHPLC-tier autosampler rated to 70 MPa with sub-30-second injection cycles; an optional 5-solvent flush system pushes carryover toward zero for trace-level QC/release methods. | Analytical (QC) | Perpetual | Platform-specific | High |
| JASCO Japan | AS-4250 Autosampler UHPLC-tier sibling of the AS-4150, rated to 130 MPa with tighter injection precision — JASCO's top-of-line LC-4000 autosampler for high-resolution UHPLC QC methods. | Analytical (QC) | Perpetual | Platform-specific | High |
| JASCO Japan | AS-4058 Autosampler Large-volume/preparative member of the LC-4000 autosampler family, standard up to 5 mL injections (10 mL optional) for prep-scale and semi-prep QC workflows where analytical-tier loop sizes fall short. | Analytical (QC) | Perpetual | Platform-specific | Med |
| JASCO Japan | AS-4550 Compact Autosampler Space-saving 15 cm-wide autosampler that can be bolted onto an existing (including non-JASCO) LC stack via keypad or RS-232 control, rather than requiring the full LC-4000 system controller. | Analytical (QC) | Perpetual | Vendor-agnostic | High |
| KNAUER Germany | AZURA AS 6.1L Autosampler KNAUER's flagship AZURA-series autosampler, offered in analytical, preparative, and biocompatible configurations sharing one chassis; the analytical build adds an ILD valve that depressurizes the loop pre-aspiration to prevent solvent dilution of the sample. | Analytical (QC) | Perpetual | Platform-specific | High |
| KNAUER Germany | PLATINblue AS-1 Autosampler Faster UHPLC-tier autosampler for KNAUER's PLATINblue system — sub-15-second injections (under 60 seconds with a full needle wash) aimed at high-throughput UHPLC QC/release testing, versus the AZURA line's HPLC/prep focus. | Analytical (QC) | Perpetual | Platform-specific | High |
| PerkinElmer United States | Flexar LC Autosampler Modular autosampler for the Flexar HPLC platform; offers three injection modes (full loop, partial fill, µL sampling) with no sample waste and an optional Peltier-cooled sample compartment for temperature-sensitive QC samples. | Analytical (QC) | Perpetual | Platform-specific | Med |
| PerkinElmer United States | LC 300 Autosampler UHPLC-tier autosampler built for the LC 300 system, using PerkinElmer's patented 7-port Intermediate Loop Decompression (ILD) valve to depressurize the loop before sampling — improving injection accuracy/reproducibility and extending column life. | Analytical (QC) | Perpetual | Platform-specific | Med |
| PerkinElmer United States | Series 200 LC Autosampler Long-running, widely-deployed autosampler explicitly marketed to work with virtually any LC system, not just PerkinElmer's; upgradable to a biocompatible flow path and supports on-board dilution/derivatization/standard-addition without extra hardware. | Analytical (QC) | Perpetual | Vendor-agnostic | Med |
| Restek Corporation United States | Certified Autosampler Vial Kits Pre-certified 2.0 mL screw-thread vial/cap/septa kits, batch-tested for dimensional fit, septum reseal, and LC/GC extractable residue so labs can skip incoming QC. Fits the standard 2 mL vial format used across virtually all GC/LC autosampler brands. | Analytical (QC) | OEM / consumables | OEM cross-brand | High |
| Restek Corporation United States | Headspace Autosampler Vials (20 mm) 20 mm crimp-top headspace vials in multiple volumes purpose-built for static/dynamic headspace autosamplers (HTA, CTC/PAL, Agilent, PerkinElmer); flat- or round-bottom options trade fill precision for sampler-arm clearance. | Analytical (QC) | OEM / consumables | OEM cross-brand | High |
| Restek Corporation United States | Hamilton-Compatible Autosampler Syringes OEM-equivalent replacement syringes (Hamilton-manufactured, Restek-supplied) sized and needle-configured to match specific autosampler brands (Agilent, CTC/PAL, Thermo, HP) — buyers must match the exact syringe model to their sampler rather than use a universal part. | Analytical (QC) | OEM / consumables | OEM cross-brand | High |
| Shimadzu Corporation Japan | Nexera SIL-40 Autosampler Series (SIL-40C / SIL-40CX3 / SIL-40XR) Shimadzu's flagship UHPLC autosampler family, sold only as part of the Nexera LC stack; the CX3 variant targets ultra-low-carryover bioanalytical/pharma QC injections. | Analytical (QC) | Perpetual | Platform-specific | High |
| Spark Holland Netherlands | Symbiosis Pico Online SPE-LC System Compact, lower-cost online-SPE autosampler positioned below Symbiosis Pharma; aimed at labs that need automated sample cleanup ahead of LC-MS/MS without flagship-level throughput. | Analytical (QC) | Perpetual | Vendor-agnostic | Med |
| Spark Holland Netherlands | CHRONECT Symbiosis Pharma Flagship high-throughput online SPE-LC-MS platform for direct injection of raw biological samples (e.g. plasma); switches between LC-MS, XLC-MS (online SPE), and AMD method-development modes for pharma bioanalysis labs. | Analytical (QC) | Perpetual | Vendor-agnostic | Med |
| Thermo Fisher Scientific United States | Vanquish Split Sampler HT Split-loop UHPLC autosampler with machine-learning-based wash-solvent monitoring and vial-bottom detection to inject from as little as 2 µL — Thermo's flagship analytical (LC) sampler for Vanquish Horizon/Flex systems, a genuinely distinct family from the GC-focused TriPlus and IC-focused Dionex. | Analytical (QC) | Perpetual | Platform-specific | High |
| Thermo Fisher Scientific United States | TriPlus RSH Autosampler GC/GC-MS robotic sample handler, not an LC autosampler — Automatic Tool Change lets one unit run liquid, headspace, and SPME Arrow injections plus sample-prep cycles (dilution, derivatization) in a single unattended sequence; ships with mounting kits for Thermo's own TRACE GCs and for major third-party GCs. | Analytical (QC) | Perpetual | OEM cross-brand | High |
| Thermo Fisher Scientific United States | Dionex AS-AP Autosampler Ion-chromatography-dedicated autosampler with an all-PEEK flow path to avoid metal contamination of IC eluents — a genuinely distinct product family from the LC-focused Vanquish and GC-focused TriPlus, built specifically around Dionex ICS integration. | Analytical (QC) | Perpetual | Platform-specific | Med |
| Waters Corporation United States | ACQUITY UPLC Sample Manager – FTN Flow-through-needle design makes the needle itself part of the high-pressure flow path, cutting dead volume and carryover — Waters' core UPLC autosampler, extendable with loop kits for larger injection volumes. | Analytical (QC) | Perpetual | Platform-specific | Med |
| Beckman Coulter (Danaher) United States | Biomek i5 / i7 Automated Workstation Danaher's flagship dual-arm liquid-handling workstation for genomics/proteomics/synthetic-biology workflows — a distinct product line from Cytiva's Xcellerex bioprocess sampling hardware despite the shared Danaher parent. | Liquid handling | Perpetual | Platform-specific | Med |
| Hamilton Company United States | Microlab STAR / STAR V Hamilton's best-known liquid-handling platform, built around proprietary CO-RE tip technology and heavily used as a genomics/diagnostics automation backbone with third-party instrument integration via Hamilton's VENUS driver library. | Liquid handling | Perpetual | OEM cross-brand | Med |
| Hamilton Company United States | Microlab Vantage 2.0 Hamilton's newer modular flagship alongside STAR, aimed at higher-throughput, tighter-integration labs; Hamilton publishes less granular public numeric detail on Vantage than on STAR. | Liquid handling | Perpetual | OEM cross-brand | Low |
| Tecan Group Switzerland | Freedom EVO / EVO-2 Series (100 / 150 / 200) Tecan's long-running modular workhorse platform, widely deployed as a cross-vendor automation hub via EVOware device drivers rather than a closed single-brand system. | Liquid handling | Perpetual | OEM cross-brand | Med |
| Tecan Group Switzerland | Fluent Automated Workstation (480 / 780 / 1080) Tecan's current-generation flagship, positioned as the successor workhorse to Freedom EVO with a smaller footprint and FluentControl software for cross-instrument work-cell integration. | Liquid handling | Perpetual | OEM cross-brand | Med |
| Analytik Jena Germany | AS-FD Autosampler (AAS Autosampler Series) Auto-dilution flame/hydride AAS autosampler for Analytik Jena's novAA/ZEEnit spectrometer lines, performing single-step dilutions up to 1:800 to extend calibration range without manual sample prep — sold as an instrument-specific accessory rather than a cross-vendor sampler. Analytik Jena has been part of the Endress+Hauser Group since 2019. | Process analytics | Perpetual | Platform-specific | High |
| Analytik Jena Germany | ICP-MS/OES Autosampler (ASX-560 platform) Teledyne CETAC-built ASX-560 autosampler integrated and sold by Analytik Jena for its ICP-OES/ICP-MS instruments, with an integrated rinse station; the SimPrep variant adds inline dilution up to 1:2500 for automated calibration-standard preparation. | Process analytics | Perpetual | Platform-specific | Med |
| Distek United States | Eclipse 5300 Dissolution Autosampler Flagship syringe-pump dissolution autosampler; valve-free, low-volume (4.5 mL) flow path minimizes carryover, with an optional lower-cost 'child' unit to sample a second bath independently. | Process analytics | Perpetual | Platform-specific | High |
| Distek United States | Evolution 4300 Dissolution Sampler Prior-generation syringe-pump dissolution sampler; single or dual 8-channel syringe pump configuration lets one unit run two independent dissolution methods with full audit logging. | Process analytics | Perpetual | Platform-specific | Med |
| Endress+Hauser Switzerland | Liquistation CSF48 Stationary refrigerated water/process sampler for continuous compliance and process monitoring (wastewater, surface water, industrial process streams), with up to 4 Memosens digital sensor channels for inline parameter logging alongside discrete bottle sampling. List pricing is quote-only per configuration. | Process analytics | Perpetual | Platform-specific | High |
| Endress+Hauser Switzerland | Liquiport CSP44 Portable, battery-powered counterpart to the CSF48 for spot/campaign water sampling in the field (e.g. stormwater or industrial discharge audits), supporting up to 2 Memosens digital sensors and an 8 m suction lift on a 19 kg chassis. | Process analytics | Perpetual | Platform-specific | High |
| Metrohm AG Switzerland | 858 Professional Sample Processor High-capacity robotic-arm sample processor for Metrohm titration/IC workflows, handling up to 999 sample positions across racks up to 42 cm diameter with inline dilution, filtration and preconcentration under MagIC Net — locked to the Metrohm instrument/software ecosystem, not vendor-agnostic. | Process analytics | Perpetual | Platform-specific | High |
| Metrohm AG Switzerland | 815 Robotic USB Sample Processor XL USB-networked robotic sample processor for parallel titration/dosing workstations, sold in 1T/2T configurations with 0–2 integrated membrane pumps; built around Metrohm's proprietary MSB device-daisy-chain interface rather than a generic automation bus. | Process analytics | Perpetual | Platform-specific | High |
| Metrohm AG Switzerland | 889 IC Sample Center Small-volume x-y-z autosampler for IC/HPLC optimized for speed (sub-10-second sample delivery) and micro-volumes down to 1 µL, with double-needle septum piercing and Pressure-Assisted Sample Aspiration across full-loop, partial-loop and pick-up injection modes. | Process analytics | Perpetual | Platform-specific | High |
| Mettler-Toledo United States | InMotion Flex Autosampler Entry-tier InMotion model for lower-volume KF and titration labs; scales from large beakers to small glass tubes but only within Mettler-Toledo's own One Click instrument ecosystem. | Process analytics | Perpetual | Platform-specific | High |
| Mettler-Toledo United States | InMotion Pro Autosampler Mid-tier InMotion model with roughly 3-4x the sample load of Flex; adds an optional barcode reader for sample tracking in regulated QC titration workflows. | Process analytics | Perpetual | Platform-specific | High |
| Mettler-Toledo United States | InMotion Max Autosampler Top-of-range InMotion tier built for high-throughput central labs running large unattended overnight KF/titration batches. | Process analytics | Perpetual | Platform-specific | High |
| SOTAX AG Switzerland | SAM-SR Sample Manager Modular sample manager sold as a SOTAX Xtend system component; functions as either a simple fraction collector or a full HPLC/UPLC direct-injection autosampler for dissolution testing. | Process analytics | Perpetual | Platform-specific | High |
| SOTAX AG Switzerland | ATF Xtend Fully Automated Dissolution System Floor-standing fully automated dissolution system that self-preps media, fills vessels, samples/filters, and self-cleans unattended end-to-end — the top tier above the semi-automated ATS Xtend. | Process analytics | Perpetual | Platform-specific | Med |
| Teledyne CETAC United States | ASX-560 Autosampler The high-capacity autosampler in CETAC's family — built to feed ICP-MS/ICP-OES/AA instruments across OEM brands (Thermo, Cytiva AKTA) rather than being locked to one analyzer vendor. | Process analytics | Perpetual | OEM cross-brand | High |
| Teledyne CETAC United States | ASX-280 Compact Autosampler Compact sibling to the ASX-560, sized for benches with less real estate; explicitly qualified across Thermo's iCE/iCAP/Element instrument families, not a single-vendor add-on. | Process analytics | Perpetual | OEM cross-brand | High |
| Teledyne CETAC United States | SimPrep Automated Sample Preparation System Liquid-handling add-on that rides on the ASX-560/280 chassis to automate dilutions, spikes and calibration curves upstream of AA/ICP-OES/ICP-MS — sample prep, not just sample delivery. | Process analytics | Perpetual | OEM cross-brand | Med |
| Xylem / YSI United States | YSI WS705 Composite/Discrete Water Sampler Portable field autosampler for stormwater/wastewater compliance monitoring; standalone unit (not tied to a specific analyzer ecosystem), built for manhole and field deployment rather than fixed-lab automation. | Process analytics | Perpetual | Vendor-agnostic | High |
| Xylem / YSI United States | YSI ProSample Automated Sampler Modular portable autosampler line with 1/4/8/24-bottle distributor-arm configurations, letting one base unit scale from spot checks to full 24-bottle discrete compliance sampling. | Process analytics | Perpetual | Vendor-agnostic | High |
| Chemspeed Technologies (Bruker) Switzerland | FLEX ISYNTH Chemspeed's flagship modular synthesis deck — SBS-plate-based, tool-exchange architecture spans conventional, microwave, photochem and reactive-gas chemistry; vendor-agnostic by design, the closest thing to a self-driving-lab backbone in the portfolio. | R&D automation | Perpetual | Vendor-agnostic | High |
| Chemspeed Technologies (Bruker) Switzerland | SWING SP Mid-tier scalable platform positioned between the entry CRYSTAL and the flagship FLEX — application-tuned for analytics/preformulation sample prep with a moving-balance gravimetric design rather than fixed liquid-handling heads. | R&D automation | Perpetual | Vendor-agnostic | Med |
| Chemspeed Technologies (Bruker) Switzerland | CRYSTAL POWDERDOSE Chemspeed's compact entry point into automation — pure gravimetric solid dispensing on a benchtop footprint, positioned as the on-ramp before a lab scales into SWING or FLEX. | R&D automation | Perpetual | Vendor-agnostic | Med |
| Unchained Labs United States | Stunner Concentration + size from the same 2 µL draw — UV/Vis, DLS and SLS in one read, cutting the multi-instrument relay biologics formulation teams usually run for quantification and aggregation checks. | R&D automation | Perpetual | Platform-specific | High |
| Unchained Labs United States | Optim 2 Dedicated high-throughput thermal/colloidal stability screener (Tm, Tagg) — narrower-purpose than the multi-modal Uncle/Aunty lines, positioned for teams that just need fast go/no-go stability ranking across formulations. | R&D automation | Perpetual | Platform-specific | Med |
| Unchained Labs United States | Sunny Suite (Sunscreen / Sunshine) LNP/nanoparticle formulation production line, not an analyzer — Sunscreen screens formulations, Sunshine scales process development toward continuous multi-liter output, both riding on reusable glass 'Sunnies' microfluidic chips. | R&D automation | Perpetual | Platform-specific | Med |
| Unchained Labs United States | Stuntman Unchained's 2026 entrant into generative-AI-driven lab automation — natural-language-to-workflow execution (built on Anthropic's Claude) on a fully modular deck, aimed squarely at Chemspeed's FLEX/SWING territory but differentiated by native LLM experiment design. | R&D automation | n/d | Vendor-agnostic | Med |
| 908 Devices United States | 908 Devices Bioprocess/PAT Portfolio (divested to Repligen) 908 Devices sold its desktop bioprocessing/PAT line (MAVEN, MAVERICK, REBEL, ZipChip) to Repligen for $70M cash in March 2025 and refocused on handheld chemical-ID devices — it no longer competes in the benchtop bioprocess/sampling market this catalog tracks. | Exited | n/d | n/d | High |
Head to head
Compare sampling products side by side
The matrix above is a census — scan it to build a shortlist. This is the other half: pick two to four product lines and see them against the same feature set. Defaults are three bioreactor-side aseptic samplers; swap in whatever you're actually weighing.
3 of 4 picked.
| Feature | Bioprocess Autosampler Eppendorf | Numera 3 SecureCell | Seg-Flow S3 Automated Sampling System Flownamics |
|---|---|---|---|
| Vendor | Eppendorf | SecureCell | Flownamics |
| Vendor country | Germany | Switzerland | United States |
| Region | Europe | Europe | North America |
| Segment | Bioprocess / aseptic | Bioprocess / aseptic | Bioprocess / aseptic |
| Pricing model | Perpetual | Perpetual | Perpetual |
| Hardware compatibility | Platform-specific | Vendor-agnostic | Vendor-agnostic |
| Price | n/d | n/d | n/d |
| Data confidence | High | High | High |
| What it is | Bolts directly onto Eppendorf's own DASware-controlled bioreactor line (DASbox, DASGIP, SciVario twin, BioFlo 320) — deep, retrofit-friendly integration but zero cross-brand support. It is a sample COLLECTOR, not an analyzer feeder: draws into a chilled vial for offline analysis, with a reusable needle and wash cycles rather than a single-use fluid path. | The deepest analyzer-agnostic sampling stack in this set — modular multiplexer, dilution, filtration and routing modules built to feed almost any downstream instrument (HPLC, Cedex Bio HT, Vi-CELL, Nova Flex) rather than lock buyers into one brand. Numbers below are Numera 3; an installed V2.x system runs to the older catalogue limits (dilution to 1:30, four analyzers), so confirm the generation before quoting. | The workhorse Seg-Flow platform — reusable pinch-valve hardware with non-contact ultrasonic sensors that routes native or pre-diluted samples from up to 8 vessels to downstream analyzers, vendor-agnostic on both ends. Two numbers not in the table because the sources disagree: dilution ratio (Flownamics publishes none; distributors quote 1:10, 1:20 and 1:25) and reactor count beyond 8 (an ASR+ / FlowWeb release is claimed to double it to 16). Storage is the separate FlowFrac 1000, not the S3 itself. |
| Source | datasheet ↗ | datasheet ↗ | datasheet ↗ |
Additional vendor specs
These come straight from each vendor's datasheet and don't use a shared vocabulary, so they're listed per product rather than aligned into rows — the table above is the genuinely like-for-like part.
Bioprocess Autosampler
- Reactors / lines
- Up to 16 (DASbox/DASGIP), 8 (SciVario twin), 4 (BioFlo 320)
- Sampling interval
- No minimum published; 5–28 min per sample depending on mode and volume
- Sample volume
- 1.5 mL or 5 mL (two selectable settings), after discarding up to 5 mL dead volume
- Sterile barrier
- Needle through per-vessel septum port + 70 % ethanol overlay; sterile-air needle curtain optional
- Sample storage
- Up to 648 × 1.5 mL vials (dual head) or 180 × 10 mL, Peltier-tempered 4–40 °C
- On-board dilution
- None documented
- Analyzer coupling
- None — vials are analysed offline; no documented liquid path to an analyzer
Numera 3
- Reactors / lines
- Up to 16 bioreactors (4 per Multiplexer Module), incl. single-use and Ambr 250
- Sampling interval
- As frequent as every 6 min
- Sample volume
- From 2.7 mL drawn per sample (post-filtration yield is lower — ask for it)
- Sterile barrier
- Pinch-valve barrier with ethanol rinse and sterile-air blow-back; autoclaved sampling line
- Sample storage
- Up to 8 plate/rack positions, Peltier-cooled 4–20 °C (racks of 40 × 1.5 mL or 24 × 4 mL)
- On-board dilution
- 1:2 to 1:100 plus reagent addition; cross-flow filtration 0.22 / 0.45 / 0.65 / 1.2 µm
- Analyzer coupling
- Up to 6 analyzers — HPLC/LC-MS (valves to 20,000 psi), cell counters, biochemistry
Seg-Flow S3 Automated Sampling System
- Reactors / lines
- 8 vessels or process streams (one ASR / ASR+ per vessel)
- Sampling interval
- 10–45 min typical cycle, depending on protocol and analyzer interface
- Sample volume
- 1.25–50 mL, user-defined (flow rate 0.1–17.0 mL/min)
- Sterile barrier
- Reagent-Manifold cleans and disinfects the fluid path after every draw; optional FISP in-situ probe adds a 0.2 µm cell-free barrier at the vessel
- Sample storage
- None on-board — via FlowFrac 1000: 14–192 positions by rack, Peltier+ to −2 °C, Chiller Plate to −10 °C
- On-board dilution
- Optional Sample-Mod S3 pre-dilution incl. serial dilution; no ratio published
- Analyzer coupling
- 1 analyzer and/or fraction collector; 4 with Sample-Mod S3. HPLC/UPLC, biochemistry, cell counters
Spec sheet
Aseptic bioprocess samplers — the deciding numbers
The rest of this page is product-level; a buyer choosing an aseptic bioreactor-side sampler needs the actual per-instrument specs. Every cell below is traceable to the vendor's own datasheet, brochure or product page — where a number isn't published, it says n/p rather than guess. Blanks cluster on the manual and passive systems for a real reason: a sterile sampling manifold has no sampling interval to publish. QB.systems is excluded (see the QB note below).
| Product | Reactors / lines | Sampling interval | Sample volume | Sterile barrier | Sample storage | On-board dilution | Analyzer coupling | Source |
|---|---|---|---|---|---|---|---|---|
Bioprocess Autosampler Eppendorf | Up to 16 (DASbox/DASGIP), 8 (SciVario twin), 4 (BioFlo 320) | No minimum published; 5–28 min per sample depending on mode and volume | 1.5 mL or 5 mL (two selectable settings), after discarding up to 5 mL dead volume | Needle through per-vessel septum port + 70 % ethanol overlay; sterile-air needle curtain optional | Up to 648 × 1.5 mL vials (dual head) or 180 × 10 mL, Peltier-tempered 4–40 °C | None documented | None — vials are analysed offline; no documented liquid path to an analyzer | |
Numera 3 SecureCell | Up to 16 bioreactors (4 per Multiplexer Module), incl. single-use and Ambr 250 | As frequent as every 6 min | From 2.7 mL drawn per sample (post-filtration yield is lower — ask for it) | Pinch-valve barrier with ethanol rinse and sterile-air blow-back; autoclaved sampling line | Up to 8 plate/rack positions, Peltier-cooled 4–20 °C (racks of 40 × 1.5 mL or 24 × 4 mL) | 1:2 to 1:100 plus reagent addition; cross-flow filtration 0.22 / 0.45 / 0.65 / 1.2 µm | Up to 6 analyzers — HPLC/LC-MS (valves to 20,000 psi), cell counters, biochemistry | |
Seg-Flow S3 Automated Sampling System Flownamics | 8 vessels or process streams (one ASR / ASR+ per vessel) | 10–45 min typical cycle, depending on protocol and analyzer interface | 1.25–50 mL, user-defined (flow rate 0.1–17.0 mL/min) | Reagent-Manifold cleans and disinfects the fluid path after every draw; optional FISP in-situ probe adds a 0.2 µm cell-free barrier at the vessel | None on-board — via FlowFrac 1000: 14–192 positions by rack, Peltier+ to −2 °C, Chiller Plate to −10 °C | Optional Sample-Mod S3 pre-dilution incl. serial dilution; no ratio published | 1 analyzer and/or fraction collector; 4 with Sample-Mod S3. HPLC/UPLC, biochemistry, cell counters | |
Seg-Flow S3G Autosampling System Flownamics | 1–8 vessels or process streams (one ASR / ASR+ per vessel) | n/p | n/p | Reagent-Manifold cleans and disinfects the fluid path after every draw; FISP 0.2 µm probe compatible | None on-board — via FlowFrac 1000: 14–192 positions by rack, Peltier+ to −2 °C, Chiller Plate to −10 °C | Optional Sample-Mod S3 pre-dilution; no ratio published | 4 analyzers and/or fraction collectors; purpose-built for blood-gas analyzers (pH, pCO2, pO2) | |
Seg-Flow PS Sampling System Flownamics | One vessel per PS module; up to 16 PS modules in parallel | n/p | 0.25–50 mL; patent-pending syringe-valve draw for high-foam / high-aeration broths | Fully disposable closed single-use fluid path, no ASR required; FISP 0.2 µm probe compatible | None on-board — no positions, no cooling; storage and chilling live downstream in a FlowFrac 1000 or the S-Series Director | None on-board; auto-dilution when paired with the S-Series Director | Standalone to a RedShift HaLCon; up to 4 analytical devices via the Director, samples carried up to 15 m | |
MAST Autosampling Solution Merck | Up to 10 sample sources per system (5 Sample Pilots per Sample Navigator, max 2 Navigators) | n/p | SP100: 10 or 55 mL per draw; SP200: 1 or 5 mL | Sample Pilot valve/pump aseptic cavity, autoclave or SIP; alcohol flush plus N₂ purge between draws | 2–8 °C retains on the optional Gilson liquid handler; position count not published | None on-board — only via the optional Gilson liquid handler, no ratio published | Up to 4 primary analyzers (Nova FLEX2, Roche Cedex BioHT, HPLC from Thermo/Agilent/Waters) plus secondary destinations | |
NovaSeptum GO Sterile Sampling System Merck | Single unit, or a 5-port / 9-port pre-loaded magazine on a multi-use Tri-clamp holder | Not applicable — an operator draws each sample; cadence is the site's SOP, not a machine spec | Bags 50–1000 mL; bottles 60–500 mL; conical 15/50 mL; syringes 1–20 mL | Single-use irradiated unit (≥25 kGy, ISO 11137); 1 or 2 mm cannula pierces the septum exactly once | None — the filled bag, bottle, conical or syringe is itself the container, carried away by hand | None — the unit only draws | None — the sealed container is walked to a bench analyzer | |
NovaSeptum SURe Sterile Sampling Assemblies Merck | Single unit, or 3- and 5-container single manifold assemblies | Not applicable — an operator draws each sample; cadence is the site's SOP, not a machine spec | Conical 15 mL; bag 100 mL; bottle 60 mL; syringe 5 and 20 mL | Single-use closed path, irradiated ≥25 kGy (ISO 11137); C-Flex heat weld or AseptiQuik S connector | None — the filled container is itself the storage, detached at the weld or connector | None — the assembly only draws | None — the sealed container is walked to a bench analyzer | |
bioPROBE single / orbitSAM Autosampler BBI-Biotech | 1 bioreactor / 1 sampling line (bioPROBE single) | From 2 min, no maximum ('from 2 min (unlimited)'); series life up to 5000 sterile samplings. Archived vendor spec table — no longer published live | From 0.5 mL per draw, set by the bioPROBE; dead-volume-free | Probe-tip valve held shut by positive pressure, opens only under negative pressure. Filterless by design, so no pore size exists to publish | 36 positions, stored 'one after another' (20 or 30 mL vials, septa optional); no cooling documented | None documented | None on the orbitSAM — it is storage only. Every analyzer claim BBI makes across four documents attaches to the multiSAM instead; the generic bioPROBE capability names no instrument and no count | |
bioPROBE quad / multiSAM Autosampler BBI-Biotech | Up to 4 bioreactors in parallel (bioPROBE quad), fully separated fluid paths | From 2 min per probe, no maximum — the bioPROBE spec table is scoped to all bioPROBE systems. No multiSAM-level or four-reactor throughput figure is published | From 0.5 mL per draw, set by the bioPROBE; dead-volume-free | Probe-tip negative-pressure valve, one per reactor; sterile-air transfer instead of a cleaning-fluid flush | Up to 384 cooled positions (also 96 × 13 mL vials, Falcon 15/50 mL, bags to 1000 mL); Peltier via Eppendorf ThermoStat C or water bath, no temperature published | None documented; optional external liquid-handling platform for sample prep | Up to 4 aseptic paths; named packs for Miltenyi MACSQuant, Beckman Vi-CELL XR and SIAS liquid handling, plus custom. How many couple at once is not published | |
coolSAM Autosampler BBI-Biotech | n/p | n/p | From 0.5 mL per draw, set by the bioPROBE | Via the bioPROBE probe-tip negative-pressure valve; samples held sterile in storage | Up to 8 cooled positions — 4 × 50 mL or 8 × 15 mL vessels (24 × 2 mL in development). Tempering 0…+100 °C ±1 °C, or ±0.5 °C over +20…+40 °C, via docked Eppendorf ThermoStat C blocks | None documented | n/p | |
BioProfile FLEX2 On-Line Autosampler (OLS) Nova Biomedical | Up to 10 bioreactors, one Remote Sampling Module per vessel, into one FLEX2 | Up to 24 samples/day/bioreactor; as fast as ~6 min per sample (10-vessel cycle ≈ 1 h) | 5.6 mL drawn per sample; the FLEX2 itself consumes 265 µL of it | Aseptic air gap between Remote Sampling Module and vessel; 3-way pinch valve isolates the reactor line | Optional Sample Retention & Cooling System: 2 or 4 Peltier racks at 4 °C (2 / 15 / 50 mL tubes). None on a base OLS | On-board FLEX2: chemistry 1:1 / 1:2 / 1:4; cell density 1:1 / 1:2 / 1:6 | One FLEX2 per OLS (one Sample Transfer Module per analyzer) | |
BioProfile FLEX2 External Sampling Module (ESM) for Ambr® Nova Biomedical | One ESM per Ambr system: 24 or 48 vessels (Ambr 15), 12 or 24 (Ambr 250 HT) | ≈6–7 min per sample (Ambr 15); ≈6–8 min (Ambr 250 HT) | 400 / 450 / 500 µL from Ambr 15; 675 µL from Ambr 250 HT | None of its own — the Ambr robot samples inside the Ambr Class II cabinet and dispenses into a deck cup | None — the cup feeds the FLEX2 directly, then runs a purge/clean cycle | On-board FLEX2: chemistry 1:1 / 1:2 / 1:4; cell density 1:1 / 1:2 / 1:6 | One FLEX2; can run alongside the Ambr Analysis Module and a cell counter | |
Ambr® Analysis Module Sartorius Stedim Biotech | Ambr 15 Cell Culture, Ambr 250 High Throughput and 250 HT Perfusion (one module per system) | ≈160 s per pH measurement cycle | 60 µL (Ambr 15) or 200 µL (Ambr 250) per pH measurement | None of its own — the Ambr robot pipettes inside the Ambr Class II cabinet into the module | None — the read is destructive: aspirated out of the cup into the flow channel, measured, then flushed with wash fluid to the waste bottle, which the manual sizes for one whole reagent pack. No positions and no active cooling on either the pH or the Raman path (manual §8.5.1.1, §8.7.5.2, §8.7.6) | None — no diluent in reagent kit 001-4B60, no dilution step anywhere in the manual's Analysis Module addendum, and the tip's volume budget is closed (700 µL gas + 60 µL sample + 50 µL gas in a 1000 µL tip). The only dilution ever measured is ~1 % incidental carryover from the Raman path's water rinse (Rowland-Jones 2020) | It IS the analyzer: pH plus Raman (metabolites, viable cell density), results returned to Ambr software | |
Xcellerex Sample Manifold Cytiva (Danaher) | 2, 4 or 10 sample bags per manifold (29041165 / 29041166 / 29041167) | Not applicable — an operator draws and seals each bag by hand | n/p | Single-use closed 'seal-and-store' manifold, joined to the bioreactor bag by tube weld; sterilisation method and dose not published | 2, 4 or 10 sealed bags retained on the manifold; passive, no temperature control | None — a passive consumable with no fluid handling of its own | None — a sealed bag is detached and carried to the lab | |
BIOne 1250 Bioprocess Control Station (automated sampling) Distek | None — no sampling line of any kind is documented | Not applicable — nothing draws a sample | Not applicable — nothing draws a sample | None of its own — with no sample path there is nothing to isolate | None | None | PAT I/O only (4 AI / 4 AO / 2 DI / 2 DO) — signal integration, no physical sample path |
n/p = not published on a fetched vendor datasheet
TCO
Perpetual vs subscription — the 5-year shape
The pricing-model column above drives more of the 5-year cost than the sticker price does. No vendor publishes list prices, so this is the shape of the decision, not a quote — the timing of the spend and where the break-even sits.
Perpetual + service
- Upfront: high — instrument capital in year 0.
- Annual: service + consumables + sampling sets (typically a fraction of capital per year).
- 5-yr shape: big year-0 hit, then a lower flat run-cost.
- Best when: you keep the unit 4+ years, have capex budget, and want the lowest long-run cost.
Subscription / instrument-as-a-service
- Upfront: low — no capital, opex from day one.
- Annual: one recurring fee bundling hardware, service and often consumables.
- 5-yr shape: flat, predictable; higher cumulative if kept long.
- Best when: you want opex not capex, a short/uncertain horizon, or flexibility to swap platforms.
Break-even rule of thumb: perpetual usually wins past roughly year 3–4; subscription wins on short horizons, capex constraints, and platform flexibility. Get each shortlisted vendor to quote both the upfront and the 5-year all-in (service + consumables + validation) — the sticker price alone hides the decision.
Recommender
Best for… — where we'd start
Four segments sit in this table; a buyer usually lives in one. Here's where to start per intent — picks are at product-line level, so confirm the specific instrument's sampling interval, volume and integration before shortlisting.
| If you're… | Start with | Why |
|---|---|---|
| Automated aseptic at-line bioreactor sampling | SecureCell (Numera) · Flownamics | Purpose-built automated aseptic sampling directly off the bioreactor — the core bioprocess niche. |
| HPLC / UHPLC analytical autosampler ecosystem | Agilent · Waters · Thermo Fisher · Shimadzu | The established analytical autosampler ecosystems — pick to match your existing chromatography stack. |
| High-throughput liquid handling / assay automation | Tecan · Hamilton | Robotic liquid handlers for assay prep and high-throughput screening. |
| At-line bioprocess metabolite / gas analysis | Nova Biomedical | Bioprocess analyzers with integrated at-line sampling for metabolites and gases. |
| Orchestrating mixed sampling hardware in software | QB.systems | A4BEE's control/automation layer over heterogeneous sampling hardware (house product — honest disclosure; see the QB note below). |
Picks are at vendor/product-line level from the positioning data above, not a per-instrument spec match. The aseptic-bioprocess segment is the deepest here; analytical and liquid-handling entries are context.
Disclosure · where QB.systems fits
Reading this comparison as A4BEE
We publish this portal, and QB.systems is our own product — so it sits in the table above as one neutral row, scored by exactly the same standard as everyone else. The honest read from the underlying analysis: QB is a credible, fast-moving, price-disruptive challenger in the bioprocess-aseptic niche, not the market's largest, most-capitalized or most-patented player. Its genuine edges are perpetual-license economics (no compounding subscription), a vendor-agnostic retrofit that spans sampling, dosing, filtration and bioreactors on one stack, and fast deployment. The trade-offs are just as real: a small team, no issued-patent estate, and a shorter peer-reviewed / GMP track record than Eppendorf, SecureCell, Merck's MAST or Flownamics. Early-stage, multi-vendor and cost-sensitive labs are where it fits best; validated commercial GMP at scale still favours the incumbents today.
About this data
Compiled from vendor datasheets, product pages and technical literature, product line by product line, current as of 2026. Segment, pricing and hardware-compatibility classifications are A4BEE's reading of that evidence, not vendor self-descriptions. Specs change; verify against the current datasheet (linked ↗) before a purchase decision. "908 Devices" is included as a market-consolidation case study — it divested its bioprocess line to Repligen in March 2025 and no longer competes here. Every row is confidence-marked; where a figure isn't public we show "n/d" rather than estimate. Vendor claims (including QB.systems') are flagged by the same confidence mark.
What's inside
- Filterable matrix of 85 autosampler / automated-sampling product lines from 38 makers, across four market segments plus R&D-automation adjacents
- Filters for segment, pricing model, hardware compatibility, region and confidence
- A pricing read — which product lines sell perpetual one-time licenses vs compounding subscription software
- A hardware-compatibility read — which platforms are vendor-agnostic retrofits vs tied to their own instruments
- Every row confidence-marked against vendor datasheets, with a datasheet link and "n/d" where a spec isn't public
- A transparent "where QB.systems fits" note — A4BEE's own product, profiled by the same standard with its trade-offs stated
Best used for
- Shortlisting a bioreactor-side aseptic autosampler product line by pricing model and hardware compatibility before requesting quotes
- Comparing analytical-autosampler product lines for a QC / release-testing lab
- Understanding total-cost-of-ownership differences between perpetual-license and subscription-software sampling product lines
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