Autosamplers & Automated Sampling Compared — 2026

The entry-level bioPROBE configuration — one probe per vessel feeding a simple auto-sorting carousel (orbitSAM), positioned as BBI-Biotech's budget automated sampler for single-reactor setups.

The scale-up configuration — four independent probes (custom quad cannula holder) feeding a single multiSAM unit that can hold hundreds of cooled samples, built for parallel small-scale bioreactor screens rather than one large vessel.

The compact option — pairs bioPROBE's sampling head with an off-the-shelf Eppendorf ThermoStat C block instead of a dedicated carousel, trading capacity for a smaller footprint and both heating and cooling flexibility.

Single-use aseptic sample-line accessory for Cytiva's Xcellerex XDR stirred-tank bioreactors and XDUO/XDM mixers — a consumable sampling component wired into the bioreactor's automation loop rather than a standalone robotic autosampler; Cytiva does not publish a fully-automated bench 'autosampler' SKU comparable to the analytical/liquid-handling entries in this set, so confidence is kept low.

Not a dedicated benchtop autosampler like Distek's dissolution line — automated/scheduled sampling from the bioreactor runs through the control station's peristaltic pumps and PAT I/O rather than a separately branded sampling module. Distinct product line serving upstream bioprocess (cell culture/microbial) work rather than QC dissolution.

Bolts directly onto Eppendorf's own DASware-controlled bioreactor line (DASbox, DASGIP, SciVario twin, BioFlo 320) — deep, retrofit-friendly integration but zero cross-brand support.

The workhorse Seg-Flow platform — reusable pinch-valve hardware with non-contact ultrasonic sensors that routes native or pre-diluted samples from up to 8 vessels to as many as 4 downstream analyzers, vendor-agnostic on both ends.

S3G is the S3 chassis reconfigured specifically for blood-gas-analyzer coupling — same pinch-valve sampling hardware, purpose-built to minimize gas exchange before pH/pCO2/pO2 analysis.

Built for cell & gene therapy: a fully disposable, low-shear fluid path replaces S3's reusable tubing set, trading reusability for GMP traceability and zero cross-contamination risk in a small-footprint, per-bioreactor module.

Originally Lonza's platform (developed in Bend, OR), acquired by Merck in 2023 — the only GMP-qualified automated aseptic sampler in this set built for large-scale stainless-steel manufacturing, not just bench-scale R&D.

Manual, not automated — a locking, no-dead-leg sampling valve for multi-use/stainless-steel processes, included as Merck's aseptic-sampling counterpart to MAST for facilities that haven't automated sampling yet.

The single-use sibling to NovaSeptum GO — same closed, no-dead-leg sampling concept, but built to be discarded with the rest of a single-use bioreactor train rather than autoclaved and reused.

Bridges Nova's FLEX2 bench analyzer to up to 10 bioreactors via automated line draws, turning a normally manual grab-sample workflow into near-hourly PAT-grade sampling — the tradeoff is you're locked into Nova's proprietary MicroSensor Card consumables for every reading.

Not a standalone sampler — it's the deck-side hardware that lets an Ambr system hand a sample cup off to a Nova FLEX2 for offline-quality chemistry, closing the loop between bioreactor control software and analyzer results without an operator in between.

In-line pH and Raman spectroscopy module rather than a discrete grab-sampler — it measures at the Ambr vessel itself, avoiding a sample-transfer step entirely, but can't handle particulate-laden or highly viscous broths.

The deepest analyzer-agnostic sampling stack in this set — modular multiplexer, dilution, filtration and routing modules built to feed almost any downstream instrument (HPLC, Cedex Bio HT, Vi-CELL, Nova Flex) rather than lock buyers into one brand.

VENDOR CORRECTION: TriVersa NanoMate is manufactured by Advion Interchim Scientific (Ithaca, NY; parent Bohui Innovation Biotechnology, via the 2020 Interchim merger) — no evidence was found that Gilson ever owned, licensed, or rebranded this product. Gilson's actual 2021 mass-spec integration was Advion's separate Compact Mass Spectrometer line folded into Gilson's VERITY prep-chromatography portfolio, a different product. Chip-based nanoelectrospray ion source confirmed compatible with multiple third-party MS platforms (Waters Xevo/SYNAPT, Sciex, others).

Agilent's standard-throughput UHPLC autosampler — single-needle design pitched at routine QA/QC and method-development labs that don't need the Multisampler's dual-needle speed or 6,000+ sample capacity.

Dual-needle design overlaps sample draw with the previous injection cycle, pushing cycle time down to ~5 s and capacity up to 6,144 samples — built for high-throughput labs running unattended batches, not routine single-sample QC.

Purpose-built loading accessory for Bio-Rad's BioLogic DuoFlow protein purification system rather than a standalone chromatography autosampler; optional Peltier cooling protects heat-sensitive protein/antibody samples during queued injections.

Legacy refrigerated autosampler for Bio-Rad's discontinued BioLogic HR/HRLC systems; no longer listed in Bio-Rad's current catalog and only available through the used-equipment secondary market, illustrating that Bio-Rad has since exited direct autosampler manufacturing in favor of NGC-to-third-party integration.

Split-loop LC-MS autosampler for Bruker's Elute+ platform, tuned for the low-carryover, high-reproducibility injections that QC/release LC-MS/MS methods (e.g., pesticide, residue panels) require; ships with PFAS-free flow-path options.

High-throughput sample-handling tier of the Elute+ platform built around a third-party CTC Analytics PAL RSI autosampler rather than a Bruker-native mechanism, expandable with additional sample trays for high-volume QC/release workflows and online extraction.

Compact NMR sample changer for Bruker Avance spectrometers, using interchangeable cassette modules with a built-in barcode reader — aimed at standard-throughput NMR QC service labs rather than the very-high-throughput SampleJet line.

Entry-level companion to SampleXpress with a smaller removable carousel, aimed at labs that need basic batch NMR sample submission without full SampleXpress cassette capacity.

Bruker's original automated NMR sample-changer line (predates SampleXpress), offered in 60- and 120-position configurations for unattended queued acquisitions across a wide range of Bruker field strengths.

Entry-level automated injector with manually exchanged tools; supports liquid, headspace and SPME sampling on one modular platform and is field-upgradeable to full PAL RTC tool-changing. OEM'd across Agilent, Thermo, Shimadzu and other GC/LC brands.

Robotic tool-changer that switches between liquid injection, headspace and SPME within one sample list in under 30 seconds, enabling unattended 24/7 multi-technique workflows. OEM'd widely across instrument brands rather than sold only under the CTC/Trajan name.

Two independent robotic heads run parallel workflows (e.g. simultaneous headspace prep plus GC/LC injection into two systems), roughly doubling throughput versus single-head RTC/RSI configurations for high-volume QC/release labs.

Gilson's high-throughput SPE/cartridge automation platform (1/3/6 mL cartridges), built as an open modular liquid handler intended to bolt onto third-party LC/MS front ends rather than a closed proprietary analytical stack.

Dedicated static-headspace autosampler that heats/shakes up to 6 vials simultaneously and relocates between GC systems from different brands in under 5 minutes; the 2000HT variant extends oven/syringe temperature for high-boiling-point applications.

Single autosampler head that covers liquid, static headspace and SPME injection and switches between the three modalities in about 5 minutes without hardware changes — a lower-cost, single-technique-at-a-time alternative to CTC's true tool-changing PAL RTC.

Routine, general-purpose autosampler in JASCO's LC-4000 series for conventional HPLC; full-loop mode maximizes reproducibility for repeat serial injections, partial-loop mode lets users change injection volume without swapping loops.

RHPLC-tier autosampler rated to 70 MPa with sub-30-second injection cycles; an optional 5-solvent flush system pushes carryover toward zero for trace-level QC/release methods.

UHPLC-tier sibling of the AS-4150, rated to 130 MPa with tighter injection precision — JASCO's top-of-line LC-4000 autosampler for high-resolution UHPLC QC methods.

Large-volume/preparative member of the LC-4000 autosampler family, standard up to 5 mL injections (10 mL optional) for prep-scale and semi-prep QC workflows where analytical-tier loop sizes fall short.

Space-saving 15 cm-wide autosampler that can be bolted onto an existing (including non-JASCO) LC stack via keypad or RS-232 control, rather than requiring the full LC-4000 system controller.

KNAUER's flagship AZURA-series autosampler, offered in analytical, preparative, and biocompatible configurations sharing one chassis; the analytical build adds an ILD valve that depressurizes the loop pre-aspiration to prevent solvent dilution of the sample.

Faster UHPLC-tier autosampler for KNAUER's PLATINblue system — sub-15-second injections (under 60 seconds with a full needle wash) aimed at high-throughput UHPLC QC/release testing, versus the AZURA line's HPLC/prep focus.

Modular autosampler for the Flexar HPLC platform; offers three injection modes (full loop, partial fill, µL sampling) with no sample waste and an optional Peltier-cooled sample compartment for temperature-sensitive QC samples.

UHPLC-tier autosampler built for the LC 300 system, using PerkinElmer's patented 7-port Intermediate Loop Decompression (ILD) valve to depressurize the loop before sampling — improving injection accuracy/reproducibility and extending column life.

Long-running, widely-deployed autosampler explicitly marketed to work with virtually any LC system, not just PerkinElmer's; upgradable to a biocompatible flow path and supports on-board dilution/derivatization/standard-addition without extra hardware.

Pre-certified 2.0 mL screw-thread vial/cap/septa kits, batch-tested for dimensional fit, septum reseal, and LC/GC extractable residue so labs can skip incoming QC. Fits the standard 2 mL vial format used across virtually all GC/LC autosampler brands.

20 mm crimp-top headspace vials in multiple volumes purpose-built for static/dynamic headspace autosamplers (HTA, CTC/PAL, Agilent, PerkinElmer); flat- or round-bottom options trade fill precision for sampler-arm clearance.

OEM-equivalent replacement syringes (Hamilton-manufactured, Restek-supplied) sized and needle-configured to match specific autosampler brands (Agilent, CTC/PAL, Thermo, HP) — buyers must match the exact syringe model to their sampler rather than use a universal part.

Shimadzu's flagship UHPLC autosampler family, sold only as part of the Nexera LC stack; the CX3 variant targets ultra-low-carryover bioanalytical/pharma QC injections.

Compact, lower-cost online-SPE autosampler positioned below Symbiosis Pharma; aimed at labs that need automated sample cleanup ahead of LC-MS/MS without flagship-level throughput.

Flagship high-throughput online SPE-LC-MS platform for direct injection of raw biological samples (e.g. plasma); switches between LC-MS, XLC-MS (online SPE), and AMD method-development modes for pharma bioanalysis labs.

Split-loop UHPLC autosampler with machine-learning-based wash-solvent monitoring and vial-bottom detection to inject from as little as 2 µL — Thermo's flagship analytical (LC) sampler for Vanquish Horizon/Flex systems, a genuinely distinct family from the GC-focused TriPlus and IC-focused Dionex.

GC/GC-MS robotic sample handler, not an LC autosampler — Automatic Tool Change lets one unit run liquid, headspace, and SPME Arrow injections plus sample-prep cycles (dilution, derivatization) in a single unattended sequence; ships with mounting kits for Thermo's own TRACE GCs and for major third-party GCs.

Ion-chromatography-dedicated autosampler with an all-PEEK flow path to avoid metal contamination of IC eluents — a genuinely distinct product family from the LC-focused Vanquish and GC-focused TriPlus, built specifically around Dionex ICS integration.

Flow-through-needle design makes the needle itself part of the high-pressure flow path, cutting dead volume and carryover — Waters' core UPLC autosampler, extendable with loop kits for larger injection volumes.

Danaher's flagship dual-arm liquid-handling workstation for genomics/proteomics/synthetic-biology workflows — a distinct product line from Cytiva's Xcellerex bioprocess sampling hardware despite the shared Danaher parent.

Hamilton's best-known liquid-handling platform, built around proprietary CO-RE tip technology and heavily used as a genomics/diagnostics automation backbone with third-party instrument integration via Hamilton's VENUS driver library.

Hamilton's newer modular flagship alongside STAR, aimed at higher-throughput, tighter-integration labs; Hamilton publishes less granular public numeric detail on Vantage than on STAR.

Tecan's long-running modular workhorse platform, widely deployed as a cross-vendor automation hub via EVOware device drivers rather than a closed single-brand system.

Tecan's current-generation flagship, positioned as the successor workhorse to Freedom EVO with a smaller footprint and FluentControl software for cross-instrument work-cell integration.

Auto-dilution flame/hydride AAS autosampler for Analytik Jena's novAA/ZEEnit spectrometer lines, performing single-step dilutions up to 1:800 to extend calibration range without manual sample prep — sold as an instrument-specific accessory rather than a cross-vendor sampler. Analytik Jena has been part of the Endress+Hauser Group since 2019.

Teledyne CETAC-built ASX-560 autosampler integrated and sold by Analytik Jena for its ICP-OES/ICP-MS instruments, with an integrated rinse station; the SimPrep variant adds inline dilution up to 1:2500 for automated calibration-standard preparation.

Flagship syringe-pump dissolution autosampler; valve-free, low-volume (4.5 mL) flow path minimizes carryover, with an optional lower-cost 'child' unit to sample a second bath independently.

Prior-generation syringe-pump dissolution sampler; single or dual 8-channel syringe pump configuration lets one unit run two independent dissolution methods with full audit logging.

Stationary refrigerated water/process sampler for continuous compliance and process monitoring (wastewater, surface water, industrial process streams), with up to 4 Memosens digital sensor channels for inline parameter logging alongside discrete bottle sampling. List pricing is quote-only per configuration.

Portable, battery-powered counterpart to the CSF48 for spot/campaign water sampling in the field (e.g. stormwater or industrial discharge audits), supporting up to 2 Memosens digital sensors and an 8 m suction lift on a 19 kg chassis.

High-capacity robotic-arm sample processor for Metrohm titration/IC workflows, handling up to 999 sample positions across racks up to 42 cm diameter with inline dilution, filtration and preconcentration under MagIC Net — locked to the Metrohm instrument/software ecosystem, not vendor-agnostic.

USB-networked robotic sample processor for parallel titration/dosing workstations, sold in 1T/2T configurations with 0–2 integrated membrane pumps; built around Metrohm's proprietary MSB device-daisy-chain interface rather than a generic automation bus.

Small-volume x-y-z autosampler for IC/HPLC optimized for speed (sub-10-second sample delivery) and micro-volumes down to 1 µL, with double-needle septum piercing and Pressure-Assisted Sample Aspiration across full-loop, partial-loop and pick-up injection modes.

Entry-tier InMotion model for lower-volume KF and titration labs; scales from large beakers to small glass tubes but only within Mettler-Toledo's own One Click instrument ecosystem.

Mid-tier InMotion model with roughly 3-4x the sample load of Flex; adds an optional barcode reader for sample tracking in regulated QC titration workflows.

Top-of-range InMotion tier built for high-throughput central labs running large unattended overnight KF/titration batches.

Modular sample manager sold as a SOTAX Xtend system component; functions as either a simple fraction collector or a full HPLC/UPLC direct-injection autosampler for dissolution testing.

Floor-standing fully automated dissolution system that self-preps media, fills vessels, samples/filters, and self-cleans unattended end-to-end — the top tier above the semi-automated ATS Xtend.

The high-capacity autosampler in CETAC's family — built to feed ICP-MS/ICP-OES/AA instruments across OEM brands (Thermo, Cytiva AKTA) rather than being locked to one analyzer vendor.

Compact sibling to the ASX-560, sized for benches with less real estate; explicitly qualified across Thermo's iCE/iCAP/Element instrument families, not a single-vendor add-on.

Liquid-handling add-on that rides on the ASX-560/280 chassis to automate dilutions, spikes and calibration curves upstream of AA/ICP-OES/ICP-MS — sample prep, not just sample delivery.

Portable field autosampler for stormwater/wastewater compliance monitoring; standalone unit (not tied to a specific analyzer ecosystem), built for manhole and field deployment rather than fixed-lab automation.

Modular portable autosampler line with 1/4/8/24-bottle distributor-arm configurations, letting one base unit scale from spot checks to full 24-bottle discrete compliance sampling.

Chemspeed's flagship modular synthesis deck — SBS-plate-based, tool-exchange architecture spans conventional, microwave, photochem and reactive-gas chemistry; vendor-agnostic by design, the closest thing to a self-driving-lab backbone in the portfolio.

Mid-tier scalable platform positioned between the entry CRYSTAL and the flagship FLEX — application-tuned for analytics/preformulation sample prep with a moving-balance gravimetric design rather than fixed liquid-handling heads.

Chemspeed's compact entry point into automation — pure gravimetric solid dispensing on a benchtop footprint, positioned as the on-ramp before a lab scales into SWING or FLEX.

Concentration + size from the same 2 µL draw — UV/Vis, DLS and SLS in one read, cutting the multi-instrument relay biologics formulation teams usually run for quantification and aggregation checks.

Dedicated high-throughput thermal/colloidal stability screener (Tm, Tagg) — narrower-purpose than the multi-modal Uncle/Aunty lines, positioned for teams that just need fast go/no-go stability ranking across formulations.

LNP/nanoparticle formulation production line, not an analyzer — Sunscreen screens formulations, Sunshine scales process development toward continuous multi-liter output, both riding on reusable glass 'Sunnies' microfluidic chips.

Unchained's 2026 entrant into generative-AI-driven lab automation — natural-language-to-workflow execution (built on Anthropic's Claude) on a fully modular deck, aimed squarely at Chemspeed's FLEX/SWING territory but differentiated by native LLM experiment design.

908 Devices sold its desktop bioprocessing/PAT line (MAVEN, MAVERICK, REBEL, ZipChip) to Repligen for $70M cash in March 2025 and refocused on handheld chemical-ID devices — it no longer competes in the benchtop bioprocess/sampling market this catalog tracks.